Make, Measure, Understand, Discover,
Predict and Construct
The Netherlands Organ-on-Chip Initiative project
In our ageing society, it is more important than ever to develop treatments for devastating chronic diseases. Yet, what appears promising in the lab, often falls short in the clinical practice.
We aim to develop new platforms to better predict the effect of medicines, based on a combination of human stem cells and microchips. In this way, we learn much more about the development of diseases and accelerate the discovery of new medicines.
The Netherlands Organ-on-Chip Initiative is an NWO Gravitation project funded by the Ministry of Education, culture and Science of the government of the Netherlands.
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We had a very nice training day organised by @_Hubrecht institute. With very interesting talks by @HansClevers, @pvulto and @pe_losk. Thanks to you all for making this a very informative digital training day! #ooc #hubrecht #organonchip #training #noci
@andriesvdm 
Standards for Organs-on-Chips, and is not ashamed to say it!
https://noci-organ-on-chip.nl/why-i-am-not-ashamed-to-say-th…
‘A bug’s life in the gut and why we need chips to understand it’ – @JelleSlager
https://noci-organ-on-chip.nl/a-bugs-life-in-the-gut-and-why…
Thrilled to receive the prestigious Vici grant. Thank @wijmenga_cisca @RitsertJansen @knoers, F.Kuipers, @SashaZhernakova, @LudeFranke, @SeboWithoff, R.Weerdma, my team, colleagues, and collaborators along this journey. @UMCGgenetica @researchumcg @nociorganonchip @LifelinesNL https://twitter.com/umcg/status/1382242636191387648
Hartelijke felicitatie voor onze toponderzoekers @jingyuan_fu en Inge Zuhorn! Zij ontvangen de prestigieuze Vici-beurs @nwonieuws . Hiermee kunnen zij de komende 5 jaar een vernieuwende onderzoekslijn ontwikkelen.
Meer informatie over hun onderzoek: 
https://bit.ly/3e79RQS
Our PhD-candidate @MoerkensRenee has used the lockdown for another creative project: Baking an #organonchip cake! Check out the recipe and end result here:
https://noci-organ-on-chip.nl/a-recipe-for-organ-on-chip-fab…
#baking #lockdown #noci
Life through the eyes of a silicon wafer:
When Soul Meets Body: A journey of a silicon wafer to become an organ-on-chip. By Hande Aydogmus
https://noci-organ-on-chip.nl/when-soul-meets-body-a-journey…
Don’t miss the opportunity to read this review titled “Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases ” in which our NOCI researchers @hhtmiddelkamp and Dr. @andriesvdm participated.
https://academic.oup.com/cardiovascres/advance-article/doi/1…
We had a great online retreat today!
#noci #organonchip #mask #wearamask #staysafe
A review of the recent article by Martin Trapecar et. al. from the view of PhD candidate Lena Sophie Koch of @utwenteEN titled: “How close can we come to the human?” #noci #organonchip
https://noci-organ-on-chip.nl/how-close-can-we-come-to-the-h…
Today, our NOCI researcher @JensPuschhof from the group of @HansClevers successfully and with honors defended his PhD thesis.
Congratulations Dr. J. Puschhof!
Exciting news: Registration and abstract submission for #EUROoCS2021 is now open. We have a great lineup of keynote speakers and lots of opportunities for #PhD students and young #scientists to present their latest #OrganOnChip #TissueChip #research. Visit https://euroocs.eu/annual-meeting/
Last week we handed out a small token of appreciation to most of our PhD-Candidates and Post-Docs. Our PI Christine Mummery is showing it off in this nice picture! #noci #mask #keepsafe #christinemummery #covidmask #organonchip
Imagine being an organ-on-chip for a week, how would you feel?
NOCI PhD student @WindtLaura dived into the diary of her own chip to find out what it’s like:
https://noci-organ-on-chip.nl/my-life-as-an-organ-on-a-chip/
Our PhD candidate @hhtmiddelkamp from @UTwente has published a paper in @SciReports: “Cell type‑specific changes in transcriptomic profiles of endothelial cells, iPSC‑derived neurons and astrocytes cultured on microfuidic chips” #noci #organonchip https://www.nature.com/articles/s41598-021-81933-x
#NOCI-researcher Jeroen Stein has published a beautiful review on Heart-on-a-chip, a very dynamic field.
Discussing 2D/3D in vitro myocardial models, cutting-edge technologies and bench-to-bedside applications of #OoC research.
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(2…
Vacancy: Post-doctoral researcher in Microelectromechanical Organs-on-Chip in the ECTM group at @tudelft as part of the Netherlands Organ-on-Chip Initiative (NOCI). https://noci-organ-on-chip.nl/vacancy-post-doctoral-research…
– A Silver Lining on the Pandemic.
Contribution by @GontanCristina
https://noci-organ-on-chip.nl/a-silver-lining-on-the-pandemic/
At the end of the day everyone is still very interested in the training 
all kidding aside, thanks so much #noci @tudelft team for virtually showing us around the clean room and MEMS fabrications! #training #microfluidics #nociorganonchip #noci
Our online NOCI PhD- Postdoc training has started! Very well organised by the researchers from @tudelft . Thanks for already a great training day, especially with the provided goodiebag. #organonchip #onlinetraining #training #noci #consortium
On the 25th of November 15:00 CET we will host an online DEMO to introduce you to our #OOC tools. Register at https://bit.ly/32MkpQc
Our biologist @amrothmann will show you how to assemble the inCHIPitᵀᴹ and the comPLATEᵀᴹ. @NikoGaio will introduce you to the applications.
Our NOCI researcher Berend van Meer has just defended his PhD thesis successfully and graduated with honours (cum laude)
Congratulations Berend for doing this great work and setting the bar high for the rest of us.
#phd #phddefense #onlinedefense #organonachip #organonchip
Today the foundation of “biosciences and society” has launched a booklet (in Dutch) entitled: ‘Mini Organs-on-Chips. Towards new research models for studying disease and finding treatments’.
https://noci-organ-on-chip.nl/booklet-on-mini-organs-on-chip…
#organonchip #noci #bookrelease #organsonchips #nociorganonachip
Great opportunity for biologists thinking of moving to organ on chips in their research!
Today we announce our #OOCtransition initiative for researchers willing to transition to animal-free testing.
Biologists can apply and have the chance to receive €15,000.00.
Info here
https://www.gobiond.com/ooctransition/
@AltertoxAcademy @BioVoxBelgium , @Proefdiervrij , @peta @Centro3r
#NOCI-postdoc Berend van Meer has won the Hugo van Poelgeest award for finding alternatives of animal testing. He did so through sharing his vision of the future of drug-testing, and setting the foundation for realizing this, but also by public lectures. http://proefdiervrij.nl/winnaar-hugo-van-poelgeestprijs-2020
Exciting all day meeting with our @NWO_Science @nociorganonchip scientific advisory board to discuss progress in our exciting Gravitation program on organs-on-chip using #hiPSC! 
Already 21 PhD students involved 
@albertvdbergtwt
The retreat of the #noci is here, though with some more personal space than usual. Everyone is very happy to see each other again and to hear the latest updates on #OoCtechnology research. #ooc #organonchip
New paper from M. Dostanić et al., which is a beautiful collaboration between #TUDelft and #LUMC. Bringing cutting edge microfabrication and stem cell biology together, this paper shows a new method of creating a #heartonchip for #EHT culture. https://ieeexplore.ieee.org/document/9152964
Check out this incredible review in @NatRevDrugDisc , covering every aspect of #organonchip and where the field is at: a very complete overview of potentials, promises, pitfalls and challenges.
#MPS #microphysiologicalsystems #OoC #TissueChip @nociorganonchip https://twitter.com/NatRevDrugDisc/status/1304054499363954688
Organs-on-chips: into the next decade https://rdcu.be/b61sC – a new review by @drlucieinthesky and colleagues at @ncats_nih_gov discusses current applications and caveats for the use of organs-on-chips in drug discovery and offers suggestions for future research directions
EUROoCS and @ISSCR announce today that Stem Cell Reports will become the “home” journal for EUROoCS member publications on the use & application of stem cells, bridging the bioengineering and stem cell communities. @StemCellReports #organonchip
https://bit.ly/35h4uvv
#ISSCR and EUROoCS announce today that Stem Cell Reports will become the “home” journal for EUROoCS member publications on the use & application of stem cells, bridging the bioengineering and stem cell communities. @martinperaJAX @StemCellReports @euroocs https://bit.ly/3jSFWwO
New regulatory tools may help replace, reduce and refine animal testing. One novel tool is Microphysiological Systems. FDA invites comments on its draft definitions for Microphysiological Systems and for Organs on a Chip: https://www.fda.gov/science-research/about-science-research-…
Very interesting read on the relevance of microphysiological systems, multiorgan on chip, and bridging the translational gap between animal models and treating human diseases. #OOC #MPS #AnimalModels #StemCells
Looking to better understand organ #models & the move to Humans-on-a-Chip?
Check out our July Special Report, w/ insights from @wyssinstitute, @HesperosInc, @InSphero, @CN_Bio & many others
http://ddn-news.com/index.php?newsarticle=14430
#StemCells #microfluidics #microtissues @DonIngber @UCFORC
So proud that our celiac disease-on-chip research is awarded with the Young Investigators Presentation Award @Euroocs_conf. Extremely grateful to be part of such a motivated and collaborative team. Thanks to the @euroocs organization. Can’t wait until next year! @nociorganonchip https://twitter.com/JoramMooiweer/status/1281494424728612865
Proud to win the Young Investigators Presentation Award(!) on behalf of our whole CeD-on-chip team
@MoerkensRenee @JelleSlager @SeboWithoff. Fantastic
@Euroocs_conf 2020 meeting and honoured by the recognition of our work. Thanks to the organizers
@euroocs. @nociorganonchip https://twitter.com/nociorganonchip/status/1281219850539540490
Joram Mooiweer from the #NOCI has won the best presentation prize of the #EUROoCS conference. An amazing honor, and very well-deserved (as he had only two days to prepare his talk). #gutonchip #celiacdisease #twoyearNOCIstreak #organonchip #OoC
The @Euroocs_conf crisisteam exists of many @nociorganonchip members as well.
#organonchip #apekop #euroocs #euroocs2020 @euroocs #godmode
Berend van Meer elaborating about the infrastructure to share technology across labs on the #EUROoCS. Standardizing and qualifying the #OoCtechnology through combining core expertise, training and commercialization. Great stuff! #NOCI #OoC #Organonchip
We open the second day of @Euroocs_conf #EUROoCS2020 with @MauriceAtEcvam of EURL ECVAM. He does such a good job putting our work on organs-on-chips in a larger regulatory and societal context. Very motivating to learn about the road to impact.
Good morning #science world, we are back in the virtual auditorium kicking off another day full of #OrganOnChip science with a keynote by @MauriceAtEcvam on regulatory considerations
And again we have split up into two parallel sessions featuring presentations from great young #OrganOnChip #researchers: #Biomaterials and #technology; #Barrier and #vasculature
Joram Mooiweer just gave a talk at the #EUROoCS about the impressive work and the results he and his group achieved in the research on Celiac disease on chip. #NOCI #organsonchip
The #Neurovascularunit on a chip-field is lucky to have such a bright young researcher like Dennis Nahon, who just presented his work at the #EUROoCS conference. Wonderful vascular networks and neural structures, using the #AIMBiotech chip. #NOCI #organonchip
Really enjoyed the first day of the @Euroocs_conf. Tomorrow another exciting day full of talks about Organs-on-a-chip, including my own presentation in the Barrier and vasculature session. @nociorganonchip
Now we are back in the virtual auditorium with a breathtaking presentation from Josef Penninger talking about the use of #Organoid for #COVIDー19 research in the @penningerlab
The virtual #PosterSession has started with lively discussions around more than 130 #OrganOnChip posters. Great to see so many young scientists and so much enthusiasm and #interdisciplinary #research
Hope everyone had a great non virtual lunch. Now we are back online with two parallel sessions on “#Organoids and #Spheroids” as well as on “#Disease #Models” featuring lots of great #OrganOnChip trainees
Now we have started two parallel sessions on #Biomechanics and #Microbiome with great presentations from many early career researchers. #OrganOnChip #YoungScientists
Lena Sophie Koch just presented her hipSC-gut/brain on a chip model, with beautiful axonal culture, and containing paneth cells and goblet cells in the intestinal organoids. A very ambitious project, and very clearly presented #noci #organonachip #EUROoCS2020
Our first keynote speaker @andriesvdm presenting his amazing work on blood vessels in #OrganOnChip and why those are especially important for #COVIDー19 researchers
#EUROoCS2020 has started. @euroocs president Christine Mummery kicked off the conference. Looking forward to exciting science. Thank you to our sponsors and the organizers!
Workshop Maskless Photolithography & Indendation
Leiden, The Netherlands
4 March, 2025
NOCI Phd/PD retreat 12 (on invitation only)
Delft, the Netherlands
20-21 March, 2025
NOCI “Troppo Breve 6” meeting
Bruges, Belgium
2-4 June, 2025
Contact
Office team
Dr. Ellen Thomassen
Project manager LUMC
Leiden University Medical Center (LUMC)
Postal Zone S4-P
P.O. Box 9600
2300 RC Leiden
The Netherlands
Dennis Doorakkers
Controller LUMC
Leiden University Medical Center (LUMC)
Postal Zone J0-R
P.O. Box 9600
2300 RC Leiden
The Netherlands
The Netherlands Organ-on-Chip Initiative is an NWO Gravitation project funded by the Ministry of Education, culture and Science of the government of the Netherlands.