DISSEMINATION



Publications

  • Scalable microphysiological system to model three-dimensional blood vessels; de Graaf MNS, Cochrane A, van den Hil FE, Buijsman W, van der Meer AD, van den Berg A, Mummery CL, Orlova VV; APL Bioeng. 2019 Jun 21;3(2):026105.  10.1063/1.5090986. eCollection 2019 Jun.
  • Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes; Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen & Christine L. Mummery; Nature Communications volume 10, Article number: 4325 (2019) | 10.1038/s41467-019-12354-8
  • Celiac disease-on-chip: Modeling a multifactorial disease in vitro; Renée Moerkens, Joram Mooiweer, Sebo Withoff,and Cisca Wijmenga; United European Gastroenterology Journal 2019, Vol. 7(4) 467–476; 10.1177/2050640619836057
  • Intestinal Barrier Function in Gluten-Related Disorders; Danielle Cardoso-Silva, Deborah Delbue, Alice Itzlinger, Renée Moerkens, Sebo Withoff, Federica Branchi and Michael Schumann; Nutrients 2019, 11, 2325; 10.3390/nu11102325
  • Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli; Pleguezuelos-Manzano, C., Puschhof, J., Huber, A.R. et al.; Nature (2020); doi:10.1038/s41586-020-2080-8
  • A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte
    contractility versus substrate stiffness; Ribeiro MC, Slaats RH,…van Meer BJ, Molenaar R, Mummery CL, Claessens MMAE, Passier R. 10.1016/j.yjmcc.2020.03.008 J Mol Cell Cardiol. 2020 Apr;141:54-64.
  • A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties; M. Dostanic, L. Windt, J. M. Stein, B. J. van Meer, M. Bellin, V. Orlova, M. Mastrangeli, C.Mummery, P. M. Sarro; 10.1109/JMEMS.2020.3011196 IEEE Journal of Microelectromechanical Systems
  • Multiplexed blood–brain barrier organ-on-chip;  M. Zakharova, M. A. Palma do Carmo, M. W. van der Helm, H. Le-The, M. N. S. de Graaf, V. Orlova, A. van den Berg, A. D. van der Meer, K. Broersen and L. I. Segerink; 10.1039/D0LC00399A; Lab Chip, 2020, 20, 3132-3143
  • Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology; Cochrane A, Albers HJ, Passier R, Mummery CL, van den Berg A, Orlova VV, van der Meer AD 10.1016/j.addr.2018.06.007 Adv Drug Deliv Rev. 2018 Jun 23. pii: S0169-409X(18)30146-7.
  • Personalised organs-on-chips: functional testing for precision medicine; van den Berg A, Mummery CL, Passier R, van der Meer AD. 10.1039/c8lc00827b Lab Chip. 2019 Jan 15;19(2):198-205.
  • Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms;  Zampeta I, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, De Vrij FMS, Kushner SA, Distel B, Elgersma Y; 10.1093/hmg/ddaa194; Human Molecular Genetics, Volume 29, Issue 18, 15 September 2020, Pages 3032–3043
  • miniaturized push-pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain; F.T.G van den Brink, vd Maagdenberg et.al.; 10.1039/C8LC01137K; Lab Chip, 2019,19, 1332-1343
  • Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Noncardiomyocyte
    Contributions to Heart Disease; Giacomelli E, ….Orlova VV, Bellin M, Mummery CL; 10.1016/j.stem.2020.05.004; Cell Stem Cell. 2020 Jun 4;26(6):862-879.
  • Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives; Cao X, … Mummery CL, Orlova VV; 10.1016/j.stemcr.2019.05.003; Stem Cell Reports 2019 11;12(6):1282-1297
  • Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem
    Cell-derived Cardiomyocytes; Saleem U, van Meer BJ, …. Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C.; 10.1093/toxsci/kfaa058; Toxicol Sci. 2020 Jul 1;176(1):103-123
  • Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer
    cells in a microfluidic device; Job Komen, Eiko Y. Westerbeek, Ruben W. Kolkman, Julia Roesthuis, Caroline Lievens, Albert van
    den Berg and Andries D. van der Meer; 10.1039/D0LC00419G; Lab Chip, 2020, 20, 3167-3178
  • Quantifying Ca 2+ signaling and contraction in vascular pericytes and smooth muscle cells; Halaidych OV, Mummery CL, Orlova VV; 10.1016/j.bbrc.2019.03.143; Biochem Biophys Res Commun. 2019 May 21;513(1):112-118.
  • Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced
    Pluripotent Stem Cells; Cao X, van den Hil FE, Mummery CL, Orlova VV; 10.1002/cpsc.108; Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e108.
  • Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived
    Endothelial Cells (hiPSC-ECs); Halaidych OV, vd Hil FE, Mummery CL, Orlova VV.; 10.3791/58678; Journal of Visualized Experiments e58678 (2018)
  • Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells; Halaidych OV, Cochrane A, vd Hil FE, Mummery CL, Orlova VV.; 10.1016/j.stemcr.2019.02.003; Stem Cell Reports 2019 12(4):647-656
  • Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells; Pleguezuelos-Manzano, C., Puschhof, J., van den Brink, S., Geurts, V., Beumer, J., Clevers, H.; 10.1002/cpim.106; CurrentProtocols in Immunology, 130, e106.
  • Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNgamma
    signalling in celiac disease; A. van der Graaf, Maria Zorro, …, Joram Mooiweer, …, Vinod Kumar, …, Yang Li, Lude Franke, Sebo
    Withoff, Cisca Wijmenga, Serena Sanna, Iris Jonkers.; 10.1101/2020.03.04.973487; BioRxiv
  • Modelling cancer immunomodulation using epithelial organoid cultures; Bar-Ephraim, Y.E., Kretzschmar, K., Asra, P., Jongh, E. de, Boonekamp, K.E., Drost, J., Gorp, J. van, Pronk, A., Smakman, N., Gan, I.J., Sebestyén Z, Kuball J, Vries R.G.J., Clevers H;
    10.1101/377655 2018: BioRxiv 377655
  • The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons; Tonazzini, I., Woerden, G., Masciullo, C., Mientjes, E., Elgersma, Y., Cecchini, M. (2019).; 10.1186/s13229-019-0293-1 Molecular Autism 10(1), 41.
  • Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder; De Jong JO, Llapashtica C, Strauss K, Provenzano F, Sun Y, Cortese GP, Brigatti KW, Corneo B, Migliori B, Kushner SA, Kellendonk C, Javitch JA, Xu B, Markx S; 10.1101/739391v1 BioRxiv

Popularised dissemination

  • “Een hart zo groot als een speldenknop”; interview with NOCI PI Christine Mummery about the heart-on-a-chip (Dutch); NRC; link
  • “Glutenintolerantie onderzoeken met mini-darmpjes”; FOCUS wetenschap Podcast van NPO Radio 1 with Sebo Withoff; link
  • “Your heart on a chip?” Berend van Meer | TEDxUniversiteitVanAmsterdam; link
  • “Mini-organen” Het Klokhuis episode featuring Christine Mummery and Berend van Meer (Dutch); link

Videos

The Netherlands Organ-on-Chip Initiative (NOCI) project

Cayetano Pleguezuelos-Manzano, Jens Puschhof and Axel Rosendahl Huber explain their research on genotoxic E. coli bacteria. Credit: DEMCON | nymus 3D and Melanie Fremery, ©Hubrecht Institute.

Christine Mummery in NOS Journaal (8 May 2017) on the NOCI Project

‘Het Klokhuis” on Dutch children’s tv eopsidoe about organs on chips featuring Christine Mummery and Berend van Meer:
https://www.zapp.nl/programmas/het-klokhuis/gemist/VPWON_1260561

 

Christine Mummery in Eenvandaag (1 aug 2017) about Organs-on-chips (in Dutch)

Berend van Meer giving the talk; “Your heart on a chip?” at the TEDx Universiteit van Amsterdam

On Wednesday 1 April 2020, Christine Mummery, professor of Developmental Biology at Leiden University Medical Centre, explained on Dutch television why we still need animal testing. You can see the broadcast here (in Dutch, 11 min)