DISSEMINATION

Publications

• Scalable microphysiological system to model three-dimensional blood vessels; de Graaf MNS, Cochrane A, van den Hil FE, Buijsman W, van der Meer AD, van den Berg A, Mummery CL, Orlova VV; APL Bioeng. 2019 Jun 21;3(2):026105.  10.1063/1.5090986. eCollection 2019 Jun.
• Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes; Berend J. van Meer, Ana Krotenberg, Luca Sala, Richard P. Davis, Thomas Eschenhagen, Chris Denning, Leon G. J. Tertoolen & Christine L. Mummery; Nature Communications volume 10, Article number: 4325 (2019) | 10.1038/s41467-019-12354-8
• Celiac disease-on-chip: Modeling a multifactorial disease in vitro; Renée Moerkens, Joram Mooiweer, Sebo Withoff,and Cisca Wijmenga; United European Gastroenterology Journal 2019, Vol. 7(4) 467–476; 10.1177/2050640619836057
• Intestinal Barrier Function in Gluten-Related Disorders; Danielle Cardoso-Silva, Deborah Delbue, Alice Itzlinger, Renée Moerkens, Sebo Withoff, Federica Branchi and Michael Schumann; Nutrients 2019, 11, 2325; 10.3390/nu11102325
• Mutational signature in colorectal cancer caused by genotoxic pks⁺ E. coli; Pleguezuelos-Manzano, C., Puschhof, J., Huber, A.R. et al.; Nature (2020); doi:10.1038/s41586-020-2080-8
• A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte
  contractility versus substrate stiffness; Ribeiro MC, Slaats RH,…van Meer BJ, Molenaar R, Mummery CL, Claessens MMAE, Passier R. 10.1016/j.yjmcc.2020.03.008 J Mol Cell Cardiol. 2020 Apr;141:54-64.
• A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties; M. Dostanic, L. Windt, J. M. Stein, B. J. van Meer, M. Bellin, V. Orlova, M. Mastrangeli, C.Mummery, P. M. Sarro; 10.1109/JMEMS.2020.3011196 IEEE Journal of Microelectromechanical Systems
• Multiplexed blood–brain barrier organ-on-chip;  M. Zakharova, M. A. Palma do Carmo, M. W. van der Helm, H. Le-The, M. N. S. de Graaf, V. Orlova, A. van den Berg, A. D. van der Meer, K. Broersen and L. I. Segerink; 10.1039/D0LC00399A; Lab Chip, 2020, 20, 3132-3143
• Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology; Cochrane A, Albers HJ, Passier R, Mummery CL, van den Berg A, Orlova VV, van der Meer AD 10.1016/j.addr.2018.06.007 Adv Drug Deliv Rev. 2018 Jun 23. pii: S0169-409X(18)30146-7.
• Personalised organs-on-chips: functional testing for precision medicine; van den Berg A, Mummery CL, Passier R, van der Meer AD. 10.1039/c8lc00827b Lab Chip. 2019 Jan 15;19(2):198-205.
• Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms;  Zampeta I, Sonzogni M, Niggl E, Lendemeijer B, Smeenk H, De Vrij FMS, Kushner SA, Distel B, Elgersma Y; 10.1093/hmg/ddaa194; Human Molecular Genetics, Volume 29, Issue 18, 15 September 2020, Pages 3032–3043
• miniaturized push-pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain; F.T.G van den Brink, vd Maagdenberg et.al.; 10.1039/C8LC01137K; Lab Chip, 2019,19, 1332-1343
• Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Noncardiomyocyte
  Contributions to Heart Disease; Giacomelli E, ….Orlova VV, Bellin M, Mummery CL; 10.1016/j.stem.2020.05.004; Cell Stem Cell. 2020 Jun 4;26(6):862-879.
• Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives; Cao X, … Mummery CL, Orlova VV; 10.1016/j.stemcr.2019.05.003; Stem Cell Reports 2019 11;12(6):1282-1297
• Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem
  Cell-derived Cardiomyocytes; Saleem U, van Meer BJ, …. Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C.; 10.1093/toxsci/kfaa058; Toxicol Sci. 2020 Jul 1;176(1):103-123
• Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer
  cells in a microfluidic device; Job Komen, Eiko Y. Westerbeek, Ruben W. Kolkman, Julia Roesthuis, Caroline Lievens, Albert van
  den Berg and Andries D. van der Meer; 10.1039/D0LC00419G; Lab Chip, 2020, 20, 3167-3178
• Quantifying Ca 2+ signaling and contraction in vascular pericytes and smooth muscle cells; Halaidych OV, Mummery CL, Orlova VV; 10.1016/j.bbrc.2019.03.143; Biochem Biophys Res Commun. 2019 May 21;513(1):112-118.
• Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced
  Pluripotent Stem Cells; Cao X, van den Hil FE, Mummery CL, Orlova VV; 10.1002/cpsc.108; Curr Protoc Stem Cell Biol. 2020 Mar;52(1):e108.
• Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived
  Endothelial Cells (hiPSC-ECs); Halaidych OV, vd Hil FE, Mummery CL, Orlova VV.; 10.3791/58678; Journal of Visualized Experiments e58678 (2018)
• Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells; Halaidych OV, Cochrane A, vd Hil FE, Mummery CL, Orlova VV.; 10.1016/j.stemcr.2019.02.003; Stem Cell Reports 2019 12(4):647-656
• Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells; Pleguezuelos-Manzano, C., Puschhof, J., van den Brink, S., Geurts, V., Beumer, J., Clevers, H.; 10.1002/cpim.106; CurrentProtocols in Immunology, 130, e106.
• Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNgamma
  signalling in celiac disease; A. van der Graaf, Maria Zorro, …, Joram Mooiweer, …, Vinod Kumar, …, Yang Li, Lude Franke, Sebo
  Withoff, Cisca Wijmenga, Serena Sanna, Iris Jonkers.; 10.1101/2020.03.04.973487; BioRxiv
• Modelling cancer immunomodulation using epithelial organoid cultures; Bar-Ephraim, Y.E., Kretzschmar, K., Asra, P., Jongh, E. de, Boonekamp, K.E., Drost, J., Gorp, J. van, Pronk, A., Smakman, N., Gan, I.J., Sebestyén Z, Kuball J, Vries R.G.J., Clevers H;
  10.1101/377655 2018: BioRxiv 377655
• The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons; Tonazzini, I., Woerden, G., Masciullo, C., Mientjes, E., Elgersma, Y., Cecchini, M. (2019).; 10.1186/s13229-019-0293-1 Molecular Autism 10(1), 41.
• Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder; De Jong JO, Llapashtica C, Strauss K, Provenzano F, Sun Y, Cortese GP, Brigatti KW, Corneo B, Migliori B, Kushner SA, Kellendonk C, Javitch JA, Xu B, Markx S; 10.1101/739391v1 BioRxiv

Popularised dissemination

• “Een hart zo groot als een speldenknop”; interview with NOCI PI Christine Mummery about the heart-on-a-chip (Dutch); NRC; link
• “Glutenintolerantie onderzoeken met mini-darmpjes”; FOCUS wetenschap Podcast van NPO Radio 1 with Sebo Withoff; link
• “Your heart on a chip?” Berend van Meer | TEDxUniversiteitVanAmsterdam; link
• “Mini-organen” Het Klokhuis episode featuring Christine Mummery and Berend van Meer (Dutch); link

Videos

Cayetano Pleguezuelos-Manzano, Jens Puschhof and Axel Rosendahl Huber explain their research on genotoxic E. coli bacteria. Credit: DEMCON | nymus 3D and Melanie Fremery, ©Hubrecht Institute.

‘Het Klokhuis” on Dutch children’s tv eopsidoe about organs on chips featuring Christine Mummery and Berend van Meer:
https://www.zapp.nl/programmas/het-klokhuis/gemist/VPWON_1260561

Berend van Meer giving the talk; “Your heart on a chip?” at the TEDx Universiteit van Amsterdam